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MOLLY MEGRAW AND SERGEI FILICHKIN PUBLISH ON ALTERNATIVE SPLICING IN PLANTS

The following publication is among the 25 most downloaded articles in Curr. Opin. Plant Biol. in the last 90 days.

Sergei Filichkin, Henry D Priest, Molly Megraw, Todd C Mockler.  2015. Alternative splicing in plants: directing traffic at the crossroads of adaptation and environmental stress. Curr. Opin. Plant Biol. 2015, 24:125–135

 

some highlights:

  • Alternative splice site selection during eukaryotic transcript processing results in the production of multiple mature mRNA isoforms from a single gene locus.
  • Cell type, developmental stage, and environment stresses modulate splice site selection.
  • Coupling of alternative pre-mRNA splicing to nonsense-mediated decay (NMD) enables degradation of mRNAs containing NMD-eliciting features.
  • Alternative splicing (AS) occurs in both non-coding and coding transcripts and can regulate abundance of long non-coding RNAs as well a primary micro-RNAs.
  • AS plays an important role in adjustments of the plant transcriptome to environmental stresses through circadian clock.
  • Plant gene regulatory networks comprise multiple feedback loops that link translation, RNA processing, and RNA surveillance, for both coding and non-coding transcripts.