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Molly Megraw

Molly Megraw

Assistant Professor

Ph.D., 2007 University of Pennsylvania

Faculty of Center for Genome Research and Biocomputing

Office: Cordley 3044
Email: megrawm@science.oregonstate.edu

Phone: 541-737-1118

 

Research Area

Transcription Factors, microRNAs, machine learning, Arabidopsis

Description of Research

The overall scientific goal of my lab is to understand how small RNAs and Transcription Factors work together in living cells. Our current research focus is on the analysis of over-represented microRNA-Transcription-Factor regulatory structures using Arabidopsis as a model organism. This work includes both computational and wet lab components to elucidate regulatory regions on a genome-wide scale. Both portions of the lab will address questions such as the following: Where are the transcription start sites of protein coding genes and noncoding RNAs? What are the functional cis-regulatory elements in their promoter regions? Can we learn to predict and understand these elements from data by using appropriate computational methods? Can we use these ideas to discover and reliably predict small genetic circuits that are functioning in an organism for a specific purpose (e.g. to generate a "pulse" of a gene as a developmental timing event, or to enforce a particular spatial pattern within a multicellular organism)?

Teaching

MCB 668 Bioinformatics and Genomics

Research group

Post-doctoral Research Scholar

Jason Cumbie

Rotation Graduate Students

Mitra Ansariola (PhD, MCB)
Taj Morton (MS, Computer Science)

Undergraduate Students

Spencer Kisler, Microbiology
Shashank Bathula, Biology Program

Related Links

Graduate Faculty of the Molecular and Cellular Biology Program

Faculty of the Center for Genome Research and Biocomputing

Selected Publications

Click here to see publications