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We use mutant plant varieties to understand the genes necessary to make a normal, healthy corn plant. We use 1) next generation sequencing, long-read Oxford Nanopore, and chromatin structural sequencing to identify the genetic changes that cause mutations while we 2) capture comprehensive image-based measurements and fit mathematical models to compare normal and mutant development. Our work is split 60/40 between indoor laboratory work and field-based sampling in our nearby corn nursery .
Lab website: Sam Leiboff
Students will use advanced genetic pedigrees to map and characterize mutant maize phenotypes. Mapping tasks will include experimental work to prepare DNA for sequencing and/or the bioinformatic analysis of the map data to identify potential causative mutations. Mutant characterization will include high-throughput genotyping with molecular markers, field-based measurements of plant growth, high-throughput imaging of live plant tissue followed by computational image processing and modeling to identify and model mutant vs normal plant tissue shape.
Students will design and execute hypothesis-driven research with a variety of techniques. Over the summer, students will learn and deploy basic to advanced concepts in genetics and plant development, including mutant analysis of organ production and mapping-by-sequencing.